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Alongside medication, integrating lifestyle changes is essential for optimal results

Medicare: Does not cover either medication for weight loss under Part D (statutory exclusion of weight-loss drugs) Covers Mounjaro (tirzepatide for diabetes) and Ozempic (semaglutide for diabetes) under Part D Some Medicare Advantage plans cover Wegovy or Zepbound, but this is plan-specific Commercial insurance: Wegovy coverage: approximately 35% of commercial plans cover with prior authorization (as of Q1 2026) Zepbound coverage: approximately 28% of commercial plans cover with prior authorization Prior authorization typically requires documented BMI 30 (or 27 with comorbidity), previous weight-loss attempt, and prescriber attestation Cash prices (as of April 2026): Wegovy: $1,349 per month (list price) Zepbound: $1,059 per month (list price) Manufacturer savings programs reduce out-of-pocket costs for commercially insured patients but do not apply to Medicare, Medicaid, or uninsured patients in most states